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-synuclein, that is a principal element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) strain, counsel that dysfunction of your intracellular proteinase techniques, which include ubiquitin-proteasome procedure or lysosomal system, which gets rid of unnecessary